Transcript: HOTTIP:6

Basic information

LNCipedia transcript ID: HOTTIP:6 
LNCipedia gene ID: HOTTIP
Location (hg19): chr7:27240056-27241442
Strand: +
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 1286 bp
Exons: 2
Sources: Ensembl release 75 - Feb 2014; Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017
Alternative transcript names: ENST00000605136.1; ENST00000605136.5
Alternative gene names: ENSG00000243766.3; HOTTIP; ENSG00000243766.7; HOXA-AS6; RP1-170O19.3; HOXA13-AS1


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites 0 non-coding 
PhyloCSF score -135.7344 non-coding 
CPAT coding probability 1.37% non-coding 
Bazzini small ORFs 0 non-coding 

In stringent set: yes

Locus conservation

Locus conservation?
HOTTIP:6 no no no no

Available literature

  1. Lian (2016), The long noncoding RNA HOXA transcript at the distal tip promotes colorectal cancer growth partially via silencing of p21 expression., Tumour Biol.
  2. Carlson (2015), LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes., PLoS Genet.
  3. Chen (2015), Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA., Sci Rep
  4. Cheng (2015), The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration., Oncotarget
  5. Deng (2015), Long non-coding RNA HOTTIP promotes tumor growth and inhibits cell apoptosis in lung cancer., Cell. Mol. Biol. (Noisy-le-grand)
  6. Díaz-Beyá (2015), The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature., Oncotarget
  7. Ge (2015), MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma., PLoS Genet.
  8. Huang (2015), HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma., Oncotarget
  9. Ji (2015), LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway., Oncotarget
  10. Konermann (2015), Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex., Nature


LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
3.1 lnc-EVX1-3:6
4.0 HOTTIP:6
4.1 HOTTIP:6
5.0 HOTTIP:6
5.1 HOTTIP:6
5.2 HOTTIP:6

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