Transcript: lnc-DLK1-35:128

Basic information

LNCipedia transcript ID: lnc-DLK1-35:128 
HGNC Gene Symbol: lnc-DLK1-35    
HGNC Full Gene Name: maternally expressed 8, small nucleolar RNA host gene
Ensembl Gene ID: ENSG00000225746
Ensembl Transcript ID: ENST00000554369
Location (hg19): chr14:101417781-101426516
Strand: +
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 485 bp
Exons: 6
Sources: Ensembl release 64 - Sep 2011; Gencode v13; Ensembl release 68 - Jul 2012; NONCODE v4; Ensembl release 75 - Feb 2014; Ensembl release 83 - Dec 2015; Ensembl release 87 - Dec 2016; Ensembl release 90 - Aug 2017; Ensembl release 92 - Apr 2018
Alternative transcript names: ENST00000554369; ENST00000554369.1; AL132709.5-003; OTTHUMT00000414509.1; NONHSAT039862; ENST00000554369.5
Alternative gene names: ENSG00000225746; AL132709.5; ENSG00000225746.3; OTTHUMG00000029060.3; ENSG00000225746.4; ENSG00000225746.8; SNHG23; ; ENSG00000225746.9; NCRNA00024; Irm; Rian; Bsr; LINC00024; AL132709.8; MEG8; ENSG00000225746.10


RNA sequence:

Structure:

Protein coding potential

Metric Raw result Interpretation
PRIDE reprocessing 2.0 0 non-coding 
Lee translation initiation sites 0 non-coding 
PhyloCSF score -114.7088 non-coding 
CPAT coding probability 2.38% non-coding 
Bazzini small ORFs 0 non-coding 

In stringent set: yes

Locus conservation

Locus conservation?
lnc-DLK1-35:128 no no no no

Available literature

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  2. Gao (2016), Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway., Tumour Biol.
  3. Ichigozaki (2016), Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma., Exp. Dermatol.
  4. Kanduri (2016), Long noncoding RNAs: Lessons from genomic imprinting., Biochim. Biophys. Acta
  5. Kato (2016), An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy., Nat Commun
  6. Li (2016), Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas., Int. J. Oncol.
  7. Liu (2016), The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells., Int. J. Oncol.
  8. Rosa (2016), Long Noncoding RNA Regulation of Pluripotency., Stem Cells Int
  9. Su (2016), Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163., Tumour Biol.
  10. Xie (2016), Long non-coding RNAs in colorectal cancer., Oncotarget
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  12. Zhuo (2016), The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma., Mol. Carcinog.
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  29. Liu (2015), The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma., PLoS ONE
  30. Liu (2015), Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1., Int J Clin Exp Pathol
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  35. Mondal (2015), MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures., Nat Commun
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  37. Pastori (2015), The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation., Proc. Natl. Acad. Sci. U.S.A.
  38. Pei (2015), Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5., Int J Clin Exp Med
  39. Peng (2015), Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression., J. Exp. Clin. Cancer Res.
  40. Quek (2015), lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs., Nucleic Acids Res.
  41. Ren (2015), Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer., Int J Clin Exp Pathol
  42. Shi (2015), Microvascular invasion in hepatocellular carcinoma overexpression promotes cell proliferation and inhibits cell apoptosis of hepatocellular carcinoma via inhibiting miR-199a expression., Onco Targets Ther
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  44. Tantai (2015), Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer., Int J Clin Exp Pathol
  45. Wang (2015), Identification of lncRNA-associated competing triplets reveals global patterns and prognostic markers for cancer., Nucleic Acids Res.
  46. Wang (2015), Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1., Neoplasma
  47. Wang (2015), Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway., J. Huazhong Univ. Sci. Technol. Med. Sci.
  48. Wang (2015), Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma., Int J Clin Exp Med
  49. Wang (2015), Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma., PLoS ONE
  50. Yang (2015), Expression profile of long non-coding RNAs is altered in endometrial cancer., Int J Clin Exp Med
  51. Yin (2015), Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer., Tumour Biol.
  52. Yu (2015), Long non-coding RNAs and hepatocellular carcinoma., Mol Clin Oncol
  53. Zamani (2015), Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer., Phytomedicine
  54. Zhang (2015), Down-regulated long non-coding RNA MEG3 and its effect on promoting apoptosis and suppressing migration of trophoblast cells., J. Cell. Biochem.
  55. Zhang (2015), LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer: evidence from a meta-analysis., Int J Clin Exp Med
  56. Zhang (2015), Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value., Biomed Res Int
  57. Zhang (2015), Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells., Int J Clin Exp Med
  58. Zhao (2015), Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer., Int J Clin Exp Pathol
  59. Zhou (2015), MiR-141 Inhibits Gastric Cancer Proliferation by Interacting with Long Noncoding RNA MEG3 and Down-Regulating E2F3 Expression., Dig. Dis. Sci.
  60. Zhu (2015), Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells., PLoS ONE
  61. Zhuang (2015), Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription., Stem Cells
  62. Alaimo (2014), ncPred: ncRNA-Disease Association Prediction through Tripartite Network-Based Inference., Front Bioeng Biotechnol
  63. Chi (2014), Role of BC040587 as a predictor of poor outcome in breast cancer., Cancer Cell Int.
  64. Cogill (2014), Co-expression Network Analysis of Human lncRNAs and Cancer Genes., Cancer Inform
  65. DeOcesano-Pereira (2014), Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis., Nucleic Acids Res.
  66. Ding (2014), Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer., Onco Targets Ther
  67. Dong (2014), Genome-wide analysis of long noncoding RNA (lncRNA) expression in hepatoblastoma tissues., PLoS ONE
  68. Guo (2014), An integrated analysis of miRNA, lncRNA, and mRNA expression profiles., Biomed Res Int
  69. He (2014), Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis., Biochim. Biophys. Acta
  70. Jia (2014), Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma., Int. J. Cancer
  71. Kameswaran (2014), Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets., Cell Metab.
  72. Kaneko (2014), Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin., Mol. Cell
  73. Kong (2014), Quantitative assessment of short amplicons in FFPE-derived long-chain RNA., Sci Rep
  74. Li (2014), Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma., Mol Med Rep
  75. Michalik (2014), Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth., Circ. Res.
  76. Roberts (2014), The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease., Philos. Trans. R. Soc. Lond., B, Biol. Sci.
  77. Schneider (2014), The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas., Int. J. Oncol.
  78. Sheng (2014), Promoter hypermethylation influences the suppressive role of maternally expressed 3, a long non-coding RNA, in the development of epithelial ovarian cancer., Oncol. Rep.
  79. Su (2014), Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes., Oncotarget
  80. Sun (2014), Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer., Tumour Biol.
  81. Sun (2014), Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition., Mol. Cancer
  82. Xu (2014), Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression., J Hematol Oncol
  83. Yan (2014), MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1., Med. Oncol.
  84. Yang (2014), A network based method for analysis of lncRNA-disease associations and prediction of lncRNAs implicated in diseases., PLoS ONE
  85. Zhang (2014), Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers., BMC Genomics
  86. Zhao (2014), Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer., Eur Rev Med Pharmacol Sci
  87. Zhou (2014), An emerging understanding of long noncoding RNAs in kidney cancer., J. Cancer Res. Clin. Oncol.
  88. Balik (2013), MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas., J. Neurooncol.
  89. Benetatos (2013), The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis., Cell. Mol. Life Sci.
  90. Du (2013), Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer., Nat. Struct. Mol. Biol.
  91. Kapusta (2013), Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs., PLoS Genet.
  92. Kogure (2013), Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer., Genes Cancer
  93. Lempiäinen (2013), Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion., Toxicol. Sci.
  94. Liu (2013), Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6., PLoS ONE
  95. Lu (2013), Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression., BMC Cancer
  96. Luo (2013), Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression., FEBS J.
  97. Nelissen (2013), Placentas from pregnancies conceived by IVF/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions., Hum. Reprod.
  98. Qin (2013), Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis., Neoplasma
  99. Tang (2013), Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma., Biomed Res Int
  100. Wan (2013), Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway., Cell. Signal.
  101. Yang (2013), Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis., Mol. Cell
  102. Ying (2013), Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer., Mol Biosyst
  103. Zou (2013), Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo., PLoS ONE
  104. Özgür (2013), Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells., Clin. Exp. Med.
  105. Jeggari (2012), miRcode: a map of putative microRNA target sites in the long non-coding transcriptome., Bioinformatics
  106. Johnson (2012), Long non-coding RNAs in Huntington's disease neurodegeneration., Neurobiol. Dis.
  107. Kagami (2012), Paternal uniparental disomy 14 and related disorders: placental gene expression analyses and histological examinations., Epigenetics
  108. Niazi (2012), Computational analysis of functional long noncoding RNAs reveals lack of peptide-coding capacity and parallels with 3' UTRs., RNA
  109. Wang (2012), Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation., J. Cell. Biochem.
  110. Braconi (2011), microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer., Oncogene
  111. Guttman (2011), lincRNAs act in the circuitry controlling pluripotency and differentiation., Nature
  112. Huntriss (2011), Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing., Fertil. Steril.
  113. Stouder (2011), Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes., Reproduction
  114. Guttman (2010), Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs., Nat. Biotechnol.
  115. Mercer (2010), Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation., BMC Neurosci
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LNCipedia transcript ID history

LNCipedia version LNCipedia transcript ID
1.3 lnc-DLK1-8:8
3.1 lnc-DLK1-8:8
4.0 SNHG23:8
4.1 MEG8:22
5.0 MEG8:22
5.1 lnc-CYP46A1-35:129
5.2 lnc-DLK1-35:128