Transcript: lnc-DLK1-35:71
Basic information
LNCipedia transcript ID: lnc-DLK1-35:71
LNCipedia gene ID: lnc-DLK1-35
Location (hg19): chr14:101293693-101327384
Strand: +
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 17883 bp
Exons: 9
Sources: FANTOM CAT (stringent)
Alternative transcript names: ENSG00000214548.10|HBMT00000437304.1
Alternative gene names: GTL2; NCRNA00023; LINC00023; onco-lncRNA-83
RNA sequence:
Structure:
Protein coding potential
| Metric |
Raw result |
Interpretation |
| PRIDE reprocessing 2.0 |
0 |
non-coding |
| Lee translation initiation sites |
|
non-coding |
| PhyloCSF score |
16.5224 |
non-coding |
| CPAT coding probability |
18.03% |
non-coding |
| Bazzini small ORFs |
0 |
non-coding |
In stringent set:
yes
Locus conservation
| Locus conservation? |
 |
 |
 |
 |
| lnc-DLK1-35:71 |
no
|
no
|
no
|
no
|
Available literature
-
Briese
(2016),
Whole transcriptome profiling reveals the RNA content of motor axons.,
Nucleic Acids Res.
-
Gao
(2016),
Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway.,
Tumour Biol.
-
Ichigozaki
(2016),
Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma.,
Exp. Dermatol.
-
Kanduri
(2016),
Long noncoding RNAs: Lessons from genomic imprinting.,
Biochim. Biophys. Acta
-
Kato
(2016),
An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy.,
Nat Commun
-
Li
(2016),
Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas.,
Int. J. Oncol.
-
Liu
(2016),
The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells.,
Int. J. Oncol.
-
Rosa
(2016),
Long Noncoding RNA Regulation of Pluripotency.,
Stem Cells Int
-
Su
(2016),
Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163.,
Tumour Biol.
-
Xie
(2016),
Long non-coding RNAs in colorectal cancer.,
Oncotarget
-
Zhang
(2016),
Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21.,
Cancer Biol. Ther.
-
Zhuo
(2016),
The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma.,
Mol. Carcinog.
-
Atta
(2015),
Reversibility and heritability of liver fibrosis: Implications for research and therapy.,
World J. Gastroenterol.
-
Beygo
(2015),
Novel deletions affecting the MEG3-DMR provide further evidence for a hierarchical regulation of imprinting in 14q32.,
Eur. J. Hum. Genet.
-
Cabanski
(2015),
Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function.,
RNA Biol
-
Cabili
(2015),
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution.,
Genome Biol.
-
Ding
(2015),
Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients.,
Oncol Lett
-
Ding
(2015),
Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades.,
J. Exp. Clin. Cancer Res.
-
Ellinger
(2015),
The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma.,
Am J Cancer Res
-
Fan
(2015),
Erratum to: Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis.,
Genome Biol.
-
Gazy
(2015),
TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.,
PLoS ONE
-
Ge
(2015),
MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma.,
PLoS Genet.
-
Guo
(2015),
Competing endogenous RNA networks and gastric cancer.,
World J. Gastroenterol.
-
Han
(2015),
Expression patterns of long noncoding RNAs from Dlk1-Dio3 imprinted region and the potential mechanisms of Gtl2 activation during blastocyst development.,
Biochem. Biophys. Res. Commun.
-
Jiang
(2015),
Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.,
Oncotarget
-
Li
(2015),
Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior.,
Pituitary
-
Li
(2015),
Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer.,
Oncotarget
-
Liu
(2015),
Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells.,
J. Neurooncol.
-
Liu
(2015),
The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma.,
PLoS ONE
-
Liu
(2015),
Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1.,
Int J Clin Exp Pathol
-
Liu
(2015),
Identification of lncRNA MEG3 Binding Protein Using MS2-Tagged RNA Affinity Purification and Mass Spectrometry.,
Appl. Biochem. Biotechnol.
-
Luo
(2015),
Long Non-Coding RNA MEG3 Inhibits Cell Proliferation and Induces Apoptosis in Prostate Cancer.,
Cell. Physiol. Biochem.
-
Mo
(2015),
Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines.,
Stem Cell Res Ther
-
Modali
(2015),
Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors.,
Mol. Endocrinol.
-
Mondal
(2015),
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.,
Nat Commun
-
Na
(2015),
Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway.,
Int J Clin Exp Med
-
Pastori
(2015),
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.,
Proc. Natl. Acad. Sci. U.S.A.
-
Pei
(2015),
Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5.,
Int J Clin Exp Med
-
Peng
(2015),
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression.,
J. Exp. Clin. Cancer Res.
-
Quek
(2015),
lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs.,
Nucleic Acids Res.
-
Ren
(2015),
Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer.,
Int J Clin Exp Pathol
-
Shi
(2015),
Microvascular invasion in hepatocellular carcinoma overexpression promotes cell proliferation and inhibits cell apoptosis of hepatocellular carcinoma via inhibiting miR-199a expression.,
Onco Targets Ther
-
Su
(2015),
The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis.,
Biomed Res Int
-
Tantai
(2015),
Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer.,
Int J Clin Exp Pathol
-
Wang
(2015),
Identification of lncRNA-associated competing triplets reveals global patterns and prognostic markers for cancer.,
Nucleic Acids Res.
-
Wang
(2015),
Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1.,
Neoplasma
-
Wang
(2015),
Long non-coding RNA MEG3 induces renal cell carcinoma cells apoptosis by activating the mitochondrial pathway.,
J. Huazhong Univ. Sci. Technol. Med. Sci.
-
Wang
(2015),
Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma.,
Int J Clin Exp Med
-
Wang
(2015),
Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma.,
PLoS ONE
-
Yang
(2015),
Expression profile of long non-coding RNAs is altered in endometrial cancer.,
Int J Clin Exp Med
-
Yin
(2015),
Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer.,
Tumour Biol.
-
Yu
(2015),
Long non-coding RNAs and hepatocellular carcinoma.,
Mol Clin Oncol
-
Zamani
(2015),
Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer.,
Phytomedicine
-
Zhang
(2015),
Down-regulated long non-coding RNA MEG3 and its effect on promoting apoptosis and suppressing migration of trophoblast cells.,
J. Cell. Biochem.
-
Zhang
(2015),
LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer: evidence from a meta-analysis.,
Int J Clin Exp Med
-
Zhang
(2015),
Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value.,
Biomed Res Int
-
Zhang
(2015),
Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells.,
Int J Clin Exp Med
-
Zhao
(2015),
Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer.,
Int J Clin Exp Pathol
-
Zhou
(2015),
MiR-141 Inhibits Gastric Cancer Proliferation by Interacting with Long Noncoding RNA MEG3 and Down-Regulating E2F3 Expression.,
Dig. Dis. Sci.
-
Zhu
(2015),
Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells.,
PLoS ONE
-
Zhuang
(2015),
Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription.,
Stem Cells
-
Alaimo
(2014),
ncPred: ncRNA-Disease Association Prediction through Tripartite Network-Based Inference.,
Front Bioeng Biotechnol
-
Chi
(2014),
Role of BC040587 as a predictor of poor outcome in breast cancer.,
Cancer Cell Int.
-
Cogill
(2014),
Co-expression Network Analysis of Human lncRNAs and Cancer Genes.,
Cancer Inform
-
DeOcesano-Pereira
(2014),
Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis.,
Nucleic Acids Res.
-
Ding
(2014),
Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer.,
Onco Targets Ther
-
Dong
(2014),
Genome-wide analysis of long noncoding RNA (lncRNA) expression in hepatoblastoma tissues.,
PLoS ONE
-
Guo
(2014),
An integrated analysis of miRNA, lncRNA, and mRNA expression profiles.,
Biomed Res Int
-
He
(2014),
Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis.,
Biochim. Biophys. Acta
-
Jia
(2014),
Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma.,
Int. J. Cancer
-
Kameswaran
(2014),
Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.,
Cell Metab.
-
Kaneko
(2014),
Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin.,
Mol. Cell
-
Kong
(2014),
Quantitative assessment of short amplicons in FFPE-derived long-chain RNA.,
Sci Rep
-
Li
(2014),
Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma.,
Mol Med Rep
-
Michalik
(2014),
Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.,
Circ. Res.
-
Roberts
(2014),
The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease.,
Philos. Trans. R. Soc. Lond., B, Biol. Sci.
-
Schneider
(2014),
The paternally imprinted DLK1-GTL2 locus is differentially methylated in embryonal and alveolar rhabdomyosarcomas.,
Int. J. Oncol.
-
Sheng
(2014),
Promoter hypermethylation influences the suppressive role of maternally expressed 3, a long non-coding RNA, in the development of epithelial ovarian cancer.,
Oncol. Rep.
-
Su
(2014),
Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes.,
Oncotarget
-
Sun
(2014),
Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer.,
Tumour Biol.
-
Sun
(2014),
Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition.,
Mol. Cancer
-
Xu
(2014),
Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression.,
J Hematol Oncol
-
Yan
(2014),
MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1.,
Med. Oncol.
-
Yang
(2014),
A network based method for analysis of lncRNA-disease associations and prediction of lncRNAs implicated in diseases.,
PLoS ONE
-
Zhang
(2014),
Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers.,
BMC Genomics
-
Zhao
(2014),
Role of HOTAIR long noncoding RNA in metastatic progression of lung cancer.,
Eur Rev Med Pharmacol Sci
-
Zhou
(2014),
An emerging understanding of long noncoding RNAs in kidney cancer.,
J. Cancer Res. Clin. Oncol.
-
Balik
(2013),
MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas.,
J. Neurooncol.
-
Benetatos
(2013),
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis.,
Cell. Mol. Life Sci.
-
Du
(2013),
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer.,
Nat. Struct. Mol. Biol.
-
Kapusta
(2013),
Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs.,
PLoS Genet.
-
Kogure
(2013),
Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer.,
Genes Cancer
-
Lempiäinen
(2013),
Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.,
Toxicol. Sci.
-
Liu
(2013),
Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6.,
PLoS ONE
-
Lu
(2013),
Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression.,
BMC Cancer
-
Luo
(2013),
Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression.,
FEBS J.
-
Nelissen
(2013),
Placentas from pregnancies conceived by IVF/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions.,
Hum. Reprod.
-
Qin
(2013),
Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis.,
Neoplasma
-
Tang
(2013),
Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma.,
Biomed Res Int
-
Wan
(2013),
Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.,
Cell. Signal.
-
Yang
(2013),
Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.,
Mol. Cell
-
Ying
(2013),
Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer.,
Mol Biosyst
-
Zou
(2013),
Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo.,
PLoS ONE
-
Özgür
(2013),
Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells.,
Clin. Exp. Med.
-
Jeggari
(2012),
miRcode: a map of putative microRNA target sites in the long non-coding transcriptome.,
Bioinformatics
-
Johnson
(2012),
Long non-coding RNAs in Huntington's disease neurodegeneration.,
Neurobiol. Dis.
-
Kagami
(2012),
Paternal uniparental disomy 14 and related disorders: placental gene expression analyses and histological examinations.,
Epigenetics
-
Niazi
(2012),
Computational analysis of functional long noncoding RNAs reveals lack of peptide-coding capacity and parallels with 3' UTRs.,
RNA
-
Wang
(2012),
Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation.,
J. Cell. Biochem.
-
Braconi
(2011),
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer.,
Oncogene
-
Guttman
(2011),
lincRNAs act in the circuitry controlling pluripotency and differentiation.,
Nature
-
Huntriss
(2011),
Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.,
Fertil. Steril.
-
Stouder
(2011),
Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes.,
Reproduction
-
Guttman
(2010),
Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs.,
Nat. Biotechnol.
-
Mercer
(2010),
Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation.,
BMC Neurosci
-
Stadtfeld
(2010),
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.,
Nature
-
Zhao
(2010),
Genome-wide identification of polycomb-associated RNAs by RIP-seq.,
Mol. Cell
-
Hagan
(2009),
At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.,
PLoS ONE
-
Royo
(2007),
Bsr, a nuclear-retained RNA with monoallelic expression.,
Mol. Biol. Cell
-
Cavaillé
(2002),
Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region.,
Hum. Mol. Genet.
-
Charlier
(2001),
Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8.,
Genome Res.
-
Hatada
(2001),
Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening.,
J. Biochem.
-
Miyoshi
(2000),
Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q.,
Genes Cells
LNCipedia transcript ID history
| LNCipedia version |
LNCipedia transcript ID |
| 4.1 |
MEG3:77 |
| 5.0 |
MEG3:77 |
| 5.1 |
lnc-CYP46A1-35:71 |
| 5.2 |
lnc-DLK1-35:71 |